Complex Cornea Problems Treatment Centre & Research Institute | Call Us At 7206001266
LJ Eye Institute - Ambala

Academics / Fellowships

w
Contact
7206001266

Book Appointment

LIMBAL STEM CELL TRANSPLANTATION

A surgical modality to replenish or repopulate the ocular surface epithelium in an eye with limbal stem cell deficiency

Squnit Correction

Clearer Vision, Brighter Days: Leading Squint Treatment in Ambala

Lazy Eye

Kid-Friendly Magic: Ambala’s Top Treatment for Lazy Eyes in Kids

Watery Eyes

Clear Eyes, Happy Kids: Top Watery Eye Treatments in Ambala

Cataract in Kids

Tiny Eyes, Mighty Care: Ambala’s Premier Cataract Surgery for Infants

Limbal Stem cell Transplantation in Ambala City

Limbal stem cell transplantation is a surgical procedure used to restore the corneal surface when it is damaged or impaired due to conditions like limbal stem cell deficiency. The limbal stem cells, located in the corneal limbus (the border between the cornea and the sclera), are crucial for maintaining the health and integrity of the corneal epithelium. In this procedure, healthy limbal stem cells are harvested from the patient’s own eye or a donor and transplanted to the damaged area of the cornea. This helps regenerate the corneal surface, improve vision, and restore the eye’s protective functions.

Why To Choose Limbal Stem Cell Transplantation Institute For Limbal Stem Cell Transplantation

Choosing the Limbal Stem Cell Transplantation Institute for limbal stem cell transplantation ensures that you receive care from specialists with extensive expertise in this intricate procedure. The institute is equipped with advanced technology and techniques tailored to optimize the success of your transplant. Their team conducts thorough evaluations to design a personalized treatment plan that addresses your specific needs, ensuring the best possible outcomes. The institute’s commitment to innovation and ongoing research means you benefit from the latest advancements in stem cell transplantation. Additionally, their comprehensive approach includes meticulous preoperative assessments and supportive postoperative care, promoting a smooth recovery and effective restoration of corneal health and vision.

What is the success rate of limbal stem cell transplant?

Cultivated Limbal Epithelial Transplantation (CLET):

Studies have shown that CLET is as effective as direct limbal transplantation for LSCD while requiring less donor tissue and thus being safer for donor eyes. Studies of CLET have shown a 68-80% success rate.

What are the limbal stem cells called?
Limbal stem cells, also known as corneal epithelial stem cells, are unipotent stem cells located in the basal epithelial layer of the corneal limbus. They form the border between the cornea and the sclera.
How do you treat limbal stem cell deficiency?
Severe ocular surface disease can result in limbal stem cell deficiency (LSCD), a condition leading to decreased visual acuity, photophobia, and ocular pain. To restore the ocular surface in advanced stem cell deficient corneas, an autologous or allogenic limbal stem cell transplantation is performed.
Can you live a normal life after stem cell transplant?

Your social life after a stem cell transplant

Once your white cell count has recovered enough you will be able to go just about anywhere. This takes roughly 3 to 6 months but check with your doctor or nurse to be sure.

What is the limbal stem cell transplant technique?
It has been suggested that limbal transplantation may be carried out in two phases: structural reconstruction by keratolimbal allograft and associated lid surgeries, followed by surface restoration preferably with living related conjunctival limbal allograft to re-establish the limbal barrier.
Can stem cell transplant be done twice?

This could be an option if you’ve had graft failure or rejection, or for some people who have relapsed. In some cases, the same donor might be used as your first transplant, but the transplant will be done with different chemotherapy drugs.

What is the problem with limbal stem cells?
Limbal stem cell deficiency is a condition that results from a failure in limbal stem cells to properly repair and regenerate the surface of the cornea. This can lead to thinning, painful ulceration, opacity in the cornea, and eventually possible blindness.
Is stem cell transplant high risk?
Stem cell or bone marrow transplants are complex treatments that carry a significant risk of serious complications. It’s important that you’re aware of both the risks and possible benefits before treatment begins. You may wish to discuss them with your treatment team and your family.
What are the disadvantages of stem cell therapy?
The primary disadvantage of stem cell therapy is the uncertainty surrounding its long-term effects and efficacy. While many patients experience significant improvement, the outcomes can vary based on individual conditions, the type of stem cells used, and the specific treatment protocol.
What is the name of limbal stem cell?
Limbal stem cells, also known as corneal epithelial stem cells, are unipotent stem cells located in the basal epithelial layer of the corneal limbus. They form the border between the cornea and the sclera.
What are the consequences of bilateral limbal stem cell deficiency?
Limbal stem cell deficiency is a rare disease that results in both visual impairment and chronic ocular surface pain.
How do you treat limbal stem cell failure?
Lubricating drops and ointments, warm compresses to the eye, and procedures to reduce tear reabsorption (punctal occlusion) are also treatment options. For inflammation reduction, treatments can also include steroids, and the removal of uncomfortable contact lenses.

Limbal Stem Cell Transplantation Symptoms

Symptoms indicating the need for limbal stem cell transplantation may include:

  • Persistent Corneal Ulcers:Non-healing ulcers on the cornea.
  • Corneal Opacity: Clouding or loss of clarity in the cornea.
  • Severe Dry Eye:  Chronic dryness and discomfort despite treatment.
  • Redness and Irritation: Persistent redness and irritation in the eye.
  • Reduced Vision: Diminished or fluctuating vision quality.
  • Pain: Persistent eye pain or discomfort.

Risk Factors

Risk factors for limbal stem cell transplantation include:

  • Infection: Presence of active infections in the eye or surrounding areas that may increase the risk of complications.
  • Graft Rejection: Risk of the transplanted stem cells being rejected by the body’s immune system.
  • Systemic Health Issues: Conditions such as diabetes or immunosuppression that can impact healing and recovery.
  • Poor Corneal or Limbal Tissue Quality: Degradation or poor health of the donor or recipient tissue.
Cornea Surgeon Dr. Vikas Mittal

Causes of Limbal Stem Cell Transplantation

Limbal stem cell transplantation is often required due to conditions that damage or deplete the limbal stem cells, which are crucial for maintaining the corneal surface. Common causes include:

  • Chemical Burns: Exposure to harmful chemicals can destroy the limbal stem cells and lead to severe corneal damage.
  • Severe Infections: Persistent or recurrent infections, such as viral or bacterial keratitis, can damage the corneal epithelium and stem cells.
  • Trauma: Physical injury to the eye, including trauma from accidents or surgeries, can impair limbal stem cell function.
  • Autoimmune Diseases: Conditions like Sjögren’s syndrome or graft-versus-host disease can lead to chronic inflammation and damage to the corneal surface.
  • Genetic Disorders: Certain genetic conditions may affect the health of the corneal epithelium and the function of limbal stem cells.
  • Chronic Dry Eye: Severe and untreated dry eye can lead to damage of the corneal surface and limbal stem cells.

These factors can disrupt the normal regeneration of the corneal epithelium, necessitating a limbal stem cell transplant to restore the ocular surface.

In Numbers

Squint Correction

Lazy Eye Treatment

Myopia Patients

Kids Cataract Surgeries

Amblyopia (Limbal Stem Cell Transplantation) causes blurry vision in one eye when something affects how a child’s eyes are developing. As their brain ignores the weaker eye, that eye drifts out of position. Amblyopia is the most common vision issue that affects kids. It’s rare, but amblyopia can affect both eyes at the same time.

What does amblyopia look like?

You might not be able to see anything physically different in your child’s eyes if they have amblyopia. Their affected eye may not line up with the stronger eye — it might look off-center or like it’s drifting in a direction that doesn’t match where they’re looking.

Still Have Questions?

Patients Feedbacks

My 6 year old son was facing allergy in his eyes since a long time. Then we visited LJ eye hospital and consulted Dr Urvish. He is a highly efficient consultant. staff is also good.

Balram Singh

Got my son’s squint surgery done from Dr urvish vashisht. Satisfactory treatment. Staff was also polite and helpful.

Gurmeet Singh

Dr urvish vashisht is an amazing doctor. Really satisfied with the line of treatment and services.

Baljinder Singh

Empanelments

Trust Us, We Will Take Care

Book Appointment